Learn how bone turnover markers are used in the clinical setting

Osteoporosis is a silent disease characterized by a loss of bone mass and bone architecture which predisposes to fragility fractures (fractures without any trauma or after a fall from a standing height). Following vertebral fractures, kyphotic deformity and loss of self-esteem may occur. Hip fracture carries an approximate 1 year mortality equal to 20% (1,2). Following a hip fracture, loss of mobility and independence can occur. Annual fractures from osteoporosis are more common than heart attack, stroke and breast cancer combined. Epidemiologic data suggests that approximately one in two women and up to one in four men age 50 and older will break a bone due to osteoporosis. Osteoporosis is responsible for two million broken bones and $19 billion in related costs every year. By 2025, experts predict that osteoporosis will be responsible for approximately three million fractures and $25.3 billion in costs each year.