Multiplate® Analyzer

A reliable tool for testing platelet function1

Multiplate® Analyzer
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ADPTEST

Assay for the quantitative in vitro determination of platelet function following stimulation of the platelet adenosine diphosphate (ADP) receptors. The ADPtest assay may be used to detect an inhibition of the P2Y12 receptor, as well as an inhibition or absence of the GpIIb/IIIa receptor

RISTOtest

Assay for the quantitative in vitro determination of von Willebrand Factor (vWF)-and glycoprotein Ib (GpIb)-dependent platelet aggregation with whole blood samples on the Multiplate®analyze

ASPItest

Assay for the quantitative in vitro determination of platelet function triggered by arachidonic acid. The ASPItest may be used to detect an inhibition of the platelet cyclooxygenase, as well as an inhibition or absence of the GpIIb/IIIa receptor

ASA reagent

Inhibitor of cyclooxgenase. Addition of ASA reagent to the blood sample leads to reduced aggregation responses in the ASPItest and the COLtest

TRAPtest

Assay for the quantitative in vitro determination of platelet function triggered by TRAP-6. Thrombin receptor activating peptide-6 (TRAP-6) is a potent platelet activator and stimulates platelet aggregation via the thrombin receptor PAR-1. The TRAPtest may be used to detect platelet function triggered via the thrombin receptor without triggering fibrin formation

GpIIbIIIa antagonist reagent

Inhibitor of the platelet GpIIbIIIa receptor. Addition of the GpIIbIIIa reagent to the blood sample leads to strongly reduced aggregation in the TRAPtest

COLtest

Assay for the quantitative in vitro determination of platelet function triggered by collagen

Liquid Control Set

Quality control for electrical signal in impedance aggregometry based on the analysis of an artificial liquid control material

Helping to guide cost-effective therapeutic approaches

  • in coronary interventions5,13,14
  • in cardiac surgeries10, 15
  • in vascular surgeries9, 15
  • in peripheral vascular interventional procedures17 
  • prevention of stent occlusion/reocclusion16 

 

Fast and easy assessment

 

  • of platelet function from small volumes of whole blood

 

Predictivity

 

  • for tailored anti-platelet regimen
  • for stratification of bleeding risk in surgical and interventional procedures
  • aid in diagnosis of inherited PF disorders

 

Medical momentum

 

  • More than 600 Medline publications 2006 and consensus papers with Multiplate and published guidelines for PFT
  • More than 10 years’ study experience 

 

Consistent results

 

  • Standardized reagents and procedures
  • Computer-based system, operates with automatic pipette and system performance controls
References
  1. Karon, BS. et. al. (2014), Clinical Chemistry, 60:1524-1531
  2. Gresele, P. et al. (2015), Haemost., 13:314-322
  3. Harrison, P. et. al. (2013), Hematol Oncol Clin N Am, 27:411-441 
  4. Aradi, D. et. al. (2015), Throm Haemost, 113:221-230
  5. Sibbing, D. et. al. (2017), Lancet, Aug 27 [e-pub]
  6. Ranucci, M. et al. (2011), Ann Thorac Surg, 91(1):123-9
  7. Weber, C.F. et al. (2012), Anesthesiology, Sep, 117(3):531-47
  8. Rafiq, S. et al. (2016), J Card Surg, 31(9):565-71
  9. Ferraris, VA. etl al. (2012), Ann Thorac Surg, 94:1761-1781
  10. Kong, R. et al. (2014), Int Jnl Lab Hem, 37:143-147
  11. Straub, N. et al. (2013). Thromb Haemost, 111(2):290-299
  12. Pape, A. et. al (2010), ISBT Science Series, 5:161-168
  13. Aradi, D. et. al. (2014), Euro Heart J, 35:209-215
  14. Aradi, D. et. al. (2013), Int J Cardiol, 167:2140-2148
  15. Ranucci, M. et. al. (2017), Interact Cardiovasc Thorac Surg, 24:196-202
  16. Byrne, R.A. et al. (2015), Euro Heart J, 36:3320-3331
  17. Rajagopalan, S. et. al. (2007), J Vasc Surg, 46:485-490 

 

Not for diagnostic use in the US.

 

System specifications

  • High throughput

    30 tests/hour

  • Sample

    Whole blood sample anticoagulated with hirudin eliminates need for sample preparation, reduces risk of pre-analytical errors

  • Low sample volume

    only 300 μL whole blood per analysis

  • Fast turn-around time

    10 min./test

  • Easy to use

    only 3 pipetting steps